Starting a new antidepressant like Wellbutrin (bupropion) can feel uncertain. You may be curious: How long does Wellbutrin take to work? How do you feel when it begins to work? And how do you know if it's simply not the right medication for you? Being aware of what to expect may relieve anxiety and allow you to monitor your progress more efficiently. Wellbutrin typically shows early effects in 1–2 weeks, with better sleep, energy, and focus. Full benefits appear in 6–8 week